癌症治疗的协同策略：利用天然产品、药物再利用和分子靶点进行综合治疗

发布时间：2025-05-11 19:29

了解并遵医嘱进行药物治疗，如内分泌治疗和靶向治疗 #生活知识# #科技生活# #健康生活技巧# #乳腺癌#

癌症治疗的协同策略：利用天然产品、药物再利用和分子靶点进行综合治疗

IF 2.5 Q2 MULTIDISCIPLINARY SCIENCES

引用次数: 0

摘要

背景不受控制的细胞增殖是癌症发生和发展的主要原因。炎症以及炎症介质和细胞在癌症中扮演着重要角色。癌症的死亡率仅次于心脏病，位居第二。从药用植物中提取的植物化学物质为治疗炎症和癌症提供了一种天然而有效的方法。摘要正文动物研究证明，食物中的植物化学物质可作为抗氧化剂、抗衰老分子和健康促进剂，从而延长寿命。这些天然化合物包括槲皮素、表儿茶素、白藜芦醇、姜黄素、山柰酚、维生素 C 和类胡萝卜素。然而，有关人类的临床数据仍在等待中。传统的对抗疗法往往有严重的副作用。最近，药物再利用已成为一种替代策略，它具有成本低、开发时间短和现有临床数据丰富的优势。本综述阐明了合成药物的副作用、植物化学药物和非肿瘤药物的有益作用及其治疗癌症的作用机制。此外，它还重点介绍了针对分子靶点的各种癌症的临床试验数据。通过整合天然产品、药物再利用和分子靶点，我们可以开发出疗效最大化、不良反应最小化的多元疗法。这种综合方法有望提供更加个性化和有效的治疗，改善患者的预后和生活质量。未来的研究应鉴定新型天然化合物，探索现有药物的再利用机会，并阐明精确治疗的分子靶点。此外，还应该开展临床试验，以验证这些综合策略对癌症患者的疗效和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synergistic strategies for cancer treatment: leveraging natural products, drug repurposing and molecular targets for integrated therapy

Background

Uncontrolled cell proliferation is a major cause of cancer development and progression. Inflammation along with inflammatory mediators and cells play a significant role in cancer. Cancer ranks in second in mortality rates, following cardiac diseases. Phytochemicals from medicinal plants offer a natural and effective approach for treating Inflammation and cancer.

Main body of the abstract

Animal studies provide evidence that phytochemicals present in food acts as antioxidants, anti-aging molecules, and health promoters, thereby extending lifespan. These natural compounds include quercetin, epicatechin, resveratrol, curcumin, kaempferol, vitamin C and carotenoids. However, clinical data on humans is still awaited. Conventional allopathic cancer therapies often have severe side effects. Recently, drug repurposing has emerged as an alternative strategy offering lower costs, shorter development times and the advantage of existing clinical data. The primary goal of drug repurposing is to discover new uses for approved or experimental drugs.

Short conclusion

The current review elucidates the side effects of synthetic drugs and the beneficial effects of phytochemicals and non-oncological drugs along with their mechanisms of action for treating cancer. Additionally, it highlights clinical trial data for various cancers focusing on molecular targets. By integrating natural products, drug repurposing and molecular targets, we can develop multifaceted therapies that maximize efficacy and minimize adverse effects. This integrated approach promises more personalized and effective treatments, improving patient outcomes and quality of life. Future research should identifying novel natural compounds, explore repurposing opportunities for existing drugs, and elucidate molecular targets for precise therapy. Additionally, clinical trials should be conducted to validate the efficacy and safety of these combined strategies in cancer patients.

Graphical abstract

来源期刊

Beni-Suef University Journal of Basic and Applied Sciences

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Beni-Suef University Journal of Basic and Applied Sciences (BJBAS) is a peer-reviewed, open-access journal. This journal welcomes submissions of original research, literature reviews, and editorials in its respected fields of fundamental science, applied science (with a particular focus on the fields of applied nanotechnology and biotechnology), medical sciences, pharmaceutical sciences, and engineering. The multidisciplinary aspects of the journal encourage global collaboration between researchers in multiple fields and provide cross-disciplinary dissemination of findings.

癌症治疗的协同策略：利用天然产品、药物再利用和分子靶点进行综合治疗