压力一大就想睡觉？这可能是为了修复DNA

猫在睡觉时会把身体蜷成一团，这是为了保持体温。 #生活知识# #趣闻#

Stress-induced sleep (SIS) in Caenorhabditis elegansis important for restoration of cellular homeostasis and is a useful model to study the function and regulation of sleep. SIS is triggered when epidermal growth factor (EGF) activates the ALA neuron, which then releases neuropeptides to promote sleep. To further understand this behavior, we established a new model of SIS using irradiation by ultraviolet C (UVC) light. While UVC irradiation requires ALA signaling and leads to a sleep state similar to that induced by heat and other stressors, it does not induce the proteostatic stress seen with heat exposure. Based on the known genotoxic effects of UVC irradiation, we tested two genes, atl-1 and cep-1, which encode proteins that act in the DNA damage response pathway. Loss-of-function mutants of atl-1 had no defect in UVC-induced SIS but a partial loss-of-function mutant of cep-1, gk138, had decreased movement quiescence following UVC irradiation. Germline ablation experiments and tissue-specific RNA interference experiments showed that cep-1 is required somatically in neurons for its effect on SIS. The cep-1(gk138) mutant suppressed body movement quiescence controlled by EGF, indicating that CEP-1acts downstream or in parallel to ALA activation to promote quiescence in response to ultraviolet light.  

网址：压力一大就想睡觉？这可能是为了修复DNA https://www.yuejiaxmz.com/news/view/451993

相关内容

斑马鱼实验：良好的睡眠能修复神经元DNA损伤
为什么压力大就想睡觉
最近就想睡觉是什么原因：当代社会压力大导致睡眠质量下降
名人说：“睡觉是一门艺术！生命动力5800S想和你一起睡”！
Science：压力大就睡一觉，不仅能减压，还降低焦虑水平
睡觉跟压力有关吗？
晚上睡觉压力大失眠怎么办？
【压力大睡不着觉怎么办】
压力大睡不着觉怎么办
压力大睡不着觉怎么缓解

随便看看