极低卡路里饮食（VLCD）与适度能量亏空饮食对多囊卵巢综合征（PCOS）肥胖女性的影响：一项随机对照试验。

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Abstract

We performed an open-label, randomised controlled trial to compare the effects of a very-low-calorie diet (VLCD) vs. moderate energy deficit approach on body weight, body composition, free androgen index (FAI), and metabolic markers in obese women with polycystic ovary syndrome (PCOS). Forty eligible patients were randomly assigned to a VLCD ( = 21) or a conventional energy deficit approach ( = 19) over the same period. After eight weeks, both groups experienced significant weight loss; however, this was greater in the VLCD arm (-10.9% vs. -3.9%, < 0.0001). There was also a trend towards a reduction in FAI in the VLCD group compared to the energy deficit group (-32.3% vs. -7.7%, = 0.07). In the VLCD arm, two women (18%) had a biochemical remission of PCOS (FAI < 4); this was not the case for any of the participants in the energy deficit arm. There was a significant within-group increase in the sex-hormone-binding globulin ( = 0.002) and reductions in fasting blood glucose ( = 0.010) and waist to hip ratio ( = 0.04) in the VLCD arm, but not in the energy deficit arm. The VLCD resulted in significantly greater weight reduction and was accompanied by more pronounced improvements in hyperandrogenaemia, body composition, and several metabolic parameters in obese women with PCOS as compared to the energy deficit approach.

摘要

我们进行了一项开放标签、随机对照试验，比较了极低卡路里饮食（VLCD）与适度能量亏缺法对多囊卵巢综合征（PCOS）肥胖女性体重、身体成分、游离雄激素指数（FAI）和代谢标志物的影响。40 名符合条件的患者被随机分配到 VLCD 组（n = 21）或常规能量亏缺法组（n = 19），两组在同一时期接受治疗。8 周后，两组患者体重均显著减轻，但 VLCD 组的减重幅度更大（-10.9% vs. -3.9%，< 0.0001）。与能量亏缺组相比，VLCD 组 FAI 也呈下降趋势（-32.3% vs. -7.7%，= 0.07）。在 VLCD 组中，有 2 名女性（18%）出现 PCOS 的生化缓解（FAI < 4），而能量亏缺组中没有任何参与者出现这种情况。VLCD 组的性激素结合球蛋白显著增加（= 0.002），空腹血糖（= 0.010）和腰臀比（= 0.04）降低，但能量亏缺组没有这种情况。与能量亏缺法相比，VLCD 可显著减轻体重，并伴有更明显的高雄激素血症、身体成分和多项代谢参数的改善。

网址：极低卡路里饮食（VLCD）与适度能量亏空饮食对多囊卵巢综合征（PCOS）肥胖女性的影响：一项随机对照试验。 https://www.yuejiaxmz.com/news/view/1417591

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